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Funding
For currently available and previous RADx funding opportunities, please see the page.
Funded Projects
RADx Underserved Populations (RADx-UP)
Project Title:Safer At School Early Alert (SASEA)
ɲ:University of California San Diego
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Summary:This project plans to expand, evaluate, and improve the Safer at School Early Alert (SASEA) program, which uses daily wastewater and surface monitoring to detect asymptomatic SARS-CoV-2 infections among students and staff in select areas in San Diego County. The project will be extended to four large clusters of schools across the county. The proposed work will also include development of the SASEA School Neighborhood Asset Portal (SNAP) to enhance program functionality.
Project Title:Sin Duda: a community-driven approach to expand reach, access, and uptake of COVID-19 home-based tests for at risk Latinos
ɲ:Johns Hopkins University
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Summary:This project will expand on their Phase 1 project to implement and evaluate innovative implementation strategies to increase reach, access, and uptake of COVID-19 home based self-testing (HST) among low-income Latinos in Maryland by expanding the reach and uptake of HST and studying the linkage to care for those who test positive or for unvaccinated people who test negative.
Project Title:Using the multiphase optimization strategy (MOST) to optimize an intervention to increase COVID-19 testing for Black and Latino/Hispanic frontline essential workers
ɲ:New York University
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Summary:This study addresses community-engaged interventions to support COVID-19 testing in the large population of frontline essential workers in lower status occupations with the goal of boosting COVID-19 testing rates for Black and Latino/Hispanic frontline essential workers by using a multiphase optimization strategy framework.
Project Title:COVID-19 testing and vaccination social network diffusion for diverse criminal legal involved communities
ɲ:University of Chicago
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Summary:This study will test the efficacy of an implemented situation of an appropriate COVID-19 testing and vaccination social network diffusion intervention against existing COVID-19 testing and vaccine linkage. The study will explore the mechanisms for differential intervention effects at the individual and network level that affect testing and vaccine uptake, and examine the reach, effectiveness, adoption, and maintenance components of the intervention.
Project Title:Motivational enhancement to augment contingency management for SARS-CoV-2 testing and vaccination utilization among syringe exchange clients
ɲ:University of Oregon
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Summary:This study will be a randomized comparative effectiveness trial examining contingency management as compared to contingency management plus enhanced motivational interviewing for people who inject drugs (PWIDs), a population highly vulnerable to contracting COVID-19 and suffering adverse effects heightened by underlying medical conditions and social factors, such a lack of stable housing.
Project Title:SCALE UP Utah II: Community-Academic Partnership to Address COVID-19 Testing and Vaccination Among Utah Community Health Centers
ɲ:University of Utah
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Summary:This project will leverage their Phase I study partnerships and flexible text messaging outreach and patient navigation infrastructure with community health centers to investigate three population health management interventions at the interface between COVID-19 vaccination and testing.
Project Title:Puerto Rico Community Action Research and Engagement (PR-CARE) to Eliminate Disparities in Diagnostic of COVID-19 among Rural Underserved and Vulnerable Populations
ɲ:University of Puerto Rico Medical Sciences Campus
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Summary:The project identifies risk factors to COVID-19 testing and vaccine uptake for disadvantaged elderly communities in Puerto Rico through the Puerto Rico Community Action Research and Engagement (PR-CARE) initiative. The study will examine how multi-domain social determinants of health affect testing and vaccine uptake in socially vulnerable elderly populations in Puerto Rico. It aims to create permanent health policy pathways that increase health services for vulnerable populations by utilizing mobile units for COVID-19 testing and exploring participants’ willingness to be tested.
Project Title:SARS-COV-2 Screening in Dialysis Facilities: Building an Optimal Strategy to Protect High Risk Populations
ɲ:Stanford University
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Summary:The project builds on an existing partnership in dialysis facilities to implement and compare two test-based universal screening strategies and assess vaccine effectiveness. The study will also examine the infection rates of patients post-vaccination in order to devise effective screening strategies, inform vaccine doses or formulations, and protect the health of patients receiving dialysis during this pandemic.
Project Title:Community-Engaged Research on COVID-19 Testing Among Underserved and/or Vulnerable Populations Phase II
ɲ:Florida International University
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Summary:This longitudinal study employs new recruitment strategies with community partners to increase the reach of testing through RADx-UP community-engaged research by assessing changes in infection and vaccination status, studying how vaccine availability affects attitudes, beliefs and behaviors to testing, understanding changes in social demographics of health and the impact on COVID-19 testing and vaccine uptake, and the relationship between vaccine hesitancy and mental health.
Project Title:Localized mHealth approach to boosting COVID-19 testing and vaccine literacy, access, and uptake among women with criminal legal system involvement
ɲ:University of Kansas Medical Center
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Summary:This project will work to rapidly develop an mHealth intervention focused on COVID-19 literacy to study regional and individual differences in COVID-19 testing and vaccine literacy, access, and uptake. The intervention will be implemented with criminal legal system involved (CLSI) women in the three cities to boost COVID-19 literacy, testing, and uptake, and vaccination. They will be using their discoveries to develop dissemination strategies with stakeholders to push the mobile health technologies intervention to the millions of people who interface with the criminal legal system annually in the U.S.
Project Title:COVID-19 Treatment Cascade Optimization Study
ɲ:University of Illinois at Urbana- Champaign
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Summary:This project is a hybrid effectiveness implementation study where community members and researchers will work together as partners with community-based organizations in Illinois and in New Jersey to test an intervention to increase COVID-19 testing and adherence to CDC COVID-19 treatment and prevention recommendations.
Project Title:An Adaptive Intervention Trial of Home Testing with Behavioral Nudges for Improving COVID-19 Testing and Prevention among People Affected by Diabetes
ɲ:Emory University
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Summary:This project will build upon Phase I of “Promoting Engagement and COVID-19 Testing for Health” (Project PEACH) and will leverage an existing partnership between Project PEACH and the Georgia Community Engagement Alliance Against COVID-19 Disparities study to understand, design, and test in a randomized, adaptive intervention trial of at-home testing, with or without individually-targeted, text message behavioral nudges aimed at increasing COVID-19 testing uptake and preventive behaviors, including vaccination. The study populations will be 600 adults affected with diabetes.
Project Title:Identifying COVID-19 vaccine deserts using Machine Learning and Geospatial Analyses to target Community-engaged testing for vulnerable rural populations to prevent localized outbreaks
ɲ:West Virginia University
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Summary:This study builds on a Phase I project and utilizes machine learning with time series modeling and geospatial methodologies to identify communities with high COVID-19 transmissibility with lower vaccine uptake. This project will engage communities by implementing a novel community-engaged testing delivery model that leverages deep connections to place, common to persons living in Appalachia, while building strong connections with local first responders to dynamically tailor testing activities and establish a grass roots network to conduct future disease screening studies in vulnerable rural populations.
Project Title:Community Mistrust and Measures of Institutional Trustworthiness (COMMIT)
ɲ:University of Maryland, Baltimore
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Summary:This project will employ a continuous engagement approach to co-design a sustainable model for community engaged research (CEnR) partnerships with an African American (AA) church (MLBC), a chain pharmacy (CVS Health) and a CEnR leading academic program to address COVID-19 for AA and low socioeconomic status populations.
Project Title:COVID-19 and Southeast Asian Americans (SEAAs)
ɲ:California State University, Northridge
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Summary:This project aims to understand and address multi-level social, ethical, and behavioral implications of COVID-19 testing, vaccination, and its sequelae among SEAAs in the Greater Los Angeles area through a community-based approach. They will determine barriers that hinder or facilitate testing and vaccination and identify common potential gaps or assets in service delivery and areas of resiliency between groups.
Project Title:Reducing Ethical and Social Prejudicial Effects of COVID-19 Testing in Underserved Populations (RESPECT-UP)
ɲ:University of Alabama at Birmingham
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Summary:This community-engaged project aims to understand factors surrounding COVID-19 testing (e.g. access to testing, employment, food and housing insecurity) and stigma drivers (e.g. lack of knowledge, misinformation, health policies, institutional practices) in vulnerable urban and rural African American communities in Alabama. In collaboration with the community, they will develop and disseminate RESPECT-UP toolkits to study multilevel strategies to reduce COVID-19 disparities and will evaluate their effectiveness in primary care settings.
Project Title:SARS-CoV-2 in Correctional Populations: A collaborative, ethical approach to application of wastewater-based surveillance
ɲ:Emory University
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Summary:This study will use qualitative and quantitative approaches with stakeholders to inform, implement, and evaluate ethical, acceptable COVID-19 wastewater-based surveillance (WBS) in four jails. Focus groups with four jail’s leaders, jail workers, and people with recent lived jail experience will be used to inform implementation of WBS strategies in those jails.
Project Title:REACH-OUT (Research, Engagement and Action on COVID-19 Health Outcomes via Testing)
ɲ:University of Colorado, Denver
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Summary:This study will use a participatory action research approach to engage underserved and socially and/or medically vulnerable communities in Colorado to design, implement, and evaluate interventions to improve reach, uptake, and sustainability of COVID-19 testing and contact tracing.
Project Title:Identifying and addressing critical social, ethical, and behavioral factors associated with COVID-19 testing and vaccination among Spanish speakers
ɲ:Wake Forest University Health Sciences
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Summary:This study is a mixed-methods study that includes rigorous qualitative methods to refine and test NuestraSaludSegura (Our Safe Health) based on the evidence-based weCare intervention that integrates peer navigation and mHealth to increase participation and care engagement to determine the impact of the intervention on COVID-19 testing and vaccination among Spanish-speaking Latin communities.
Project Title:Community Activation to Transform Local systems (CATALYST)
ɲ:University of California, Irvine
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Summary:This study will examine barriers and processes of change in COVID-19 responses and chronic disease management interventions during the pandemic by assessing systemic factors that enhance inequities in COVID-19 testing, cases, and vaccines in areas with high social vulnerability to COVID-19, which will be analyzed to determine how advocacy efforts can be implemented by community-based organizations to shape their COVID-19 response.
Project Title:Evidence based Interventions to address Structure, System and Population Inequities in COVID-19 Screening
ɲ:University of Vermont and State Agricultural College
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Summary:This study will identify social, behavioral, structural, and policy factors that are sources of COVID-19 disparities and then test an innovative intervention to decrease COVID-19 testing inequalities and will focus on the accessibility, acceptability and use of COVID-19 testing resources in underserved and vulnerable populations in Northern New England.
Project Title:Ethno-epidemiology of HCV, HIV and Overdose associated with Drug Markets and Drug Tourism
ɲ:University of California, San Diego
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Summary:This project aims to increase access and uptake of COVID-19 testing and vaccination among people who inject drugs, a population highly vulnerable to COVID-19. The project will look at barriers and predictors of COVID-19 testing and vaccination and adapt or develop an intervention to improve their uptake, which will be piloted among a subgroup of 150 participants who have not had COVID-19 vaccination or testing.
Project Title:Addressing COVID-19 Testing Disparities in Vulnerable Populations Using a Community JITAI (Just in Time Adaptive Intervention) Approach - Phase II
ɲ:University of Texas Health Science Center at Houston
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Summary:Building on RADx-UP Phase I work, and partnerships and resources of the Center for Clinical and Translational Science (CCTS), the goal of the project is to identify dynamic disease hotspots and testing deserts in three regions of Texas to improve and expand multilevel just-in-time adaptive intervention strategies to reach vulnerable populations experiencing inequities related to COVID-19.
Project Title:Psychosocial Factors and Lupus Disease Progression Among African American Women
ɲ:Tulane University of Louisiana
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Summary: This project will identify facilitators and barriers to COVID-19 testing and vaccination and evaluate the efficacy of a peer-outreach/education intervention, including a testing/vaccine concierge program for people living with systemic lupus erythematosus (SLE) and members of their social networks—a high priority population that is disproportionately African Americanand women.
Project Title:Community-engaged partnership to reduce COVID-19 through self-testing in Hispanic and NHPI communities
ɲ:University of Arkansas for Medical Sciences
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Summary:This project will implement and evaluate access and uptake strategies of two self-testing distribution approaches (local community clinics and community-based non-profit organizations) to understand effectiveness and impact for vulnerable populations.
Project Title:Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant, Low-income and Homeless Populations, and Testing Targeted Interventions
ɲ:Maine Health
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Summary:The project will work with community partners to create and evaluate the impact of a public health intervention in the area of Cumberland County, Maine, to provide outreach, testing, and vaccination education to a large community of immigrants from sub-Saharan Africa, the Middle East, and Central America, higher-risk low-income people accessing a public health facility (with a sexually transmitted infections clinic, needle exchange, and a free clinic), and individuals experiencing homelessness. This will be a longitudinal study to understand beliefs about and knowledge of COVID-19, and barriers and beliefs about testing and vaccination.
Project Title:C2SPARC: Implementing mobile, POC COVID-19 testing in partnership with a community-based organization to reach women who use drugs
ɲ:Johns Hopkins University
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Summary:The project will examine predisposing and enabling predictors of uptake of point-of-care COVID-19 testing among a cohort of women who use drugs (N=250) in Baltimore, MD over six months.
Project Title:Optimizing SARS-CoV-2 Testing and Promotores Interventions to Serve Latinx Communities
ɲ:University of Oregon
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Summary:The project will continue to address the ongoing disparities in COVID-19 cases among underserved Latinx populations in Oregon by collaborating with state, county, and community partners to optimize testing locations across the state of Oregon and deliver a culturally tailored health intervention to increase testing, improve health behaviors, and reduce vaccine hesitancy among Latin individuals.
Project Title:Eliminating COVID-19 disparities in partnership with underserved/vulnerable transnational communities of Arizona
ɲ:Arizona State University – Tempe Campus
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Summary:This project will inform public health approaches on how to make COVID-19 testing more readily available to farm workers and other vulnerable and underserved communities living and working along the Arizona-Mexico border region.
Project Title:RI-Center for Clinical and Translational Science
ɲ:Brown University
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Summary:This project aims to identifyvaccination rates relativetoCOVID-19 positivity rates for high-risk pediatric populations, determine barriers to SARS-CoV-2 testing and community hesitancy to COVID-19 vaccination, and implement community-based approaches to increase testing and vaccination rates for high-risk children.
Project Title:Community-Engaged COVID-19 Interventions to Protect and Monitor Children
ɲ:University of Chicago
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Summary:This project addresses COVID-19 testing and vaccination hesitancy and uptake issues in vulnerable populations (e.g., low-income Black and Latinx people in the Chicagoland metro area) by partnering with a community organization to control COVID-19 spread in Chicago.
Project Title:Reaching Communities through the Design of Information Visualizations (ReDIVis) Toolbox to Address COVID-19 Vaccine Hesitancy and Uptake
ɲ:Columbia University
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Summary:This project will expand work on designing culturally congruent, health literate infographics for use in the return of COVID-19 diagnostic and testing results from a current RADx-UP award to vaccine hesitancy and uptake. The project also will also add the inclusion of South Asians and Chinese Americans to the existing Latino/a and Black populations included in the project.
Project Title:COVID-19 Testing Model for Vulnerable Populations: Revision to Address Vaccine Hesitancy and Uptake
ɲ:University of Alabama at Birmingham
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Summary:This project will use results of formative work on COVID-19 vaccine hesitancy and uptake in Alabama conducted by their Obesity Health Disparities Research Center academic community engagement and dissemination core and Alabama Community Engagement Alliance Against COVID-19 (CEAL) to design and evaluate a multi-level (community-systems- interpersonal- individual) dissemination model to decrease vaccine hesitancy that can be incorporated into existing CEAL and RADx-UP community-level and individual efforts.
Project Title:UC Davis Environmental Health Sciences Core Center
ɲ:University of California at Davis
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Summary:The project will use a three-tiered approach to address barriers to COVID-19 vaccination in predominantly Latino counties in the Central Valley of California. The three tiers include reducing vaccine hesitancy and improving vaccine uptake with continued testing and literacy-supported decision-making processes coupled with an evaluation of the impact of interventions on vaccine hesitancy.
Project Title:CATCH-UP Vaccines
ɲ:University of Oklahoma Health Sciences Center
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Summary:This project will unite academic and community partners to solve a dire need for SARS-CoV-2 vaccine uptake in rural, underserved minority, and at-risk populations. The project is an extension of the Oklahoma Shared Clinical Translational Resources project CATCH-UP (Community-engaged Approaches to Testing in Community and Healthcare settings for Underserved Populations) in partnership with community organizations who work with underserved minority and rural populations.
Project Title:Impact of Community Health Worker Home Deployment on COVID-19 Vaccine Confidence and Uptake
ɲ:Emory University
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Summary:The project will collaborate with rural community partners and utilize locally developed and tested Georgia Community Engagement Alliance Against COVID-19 (CEAL) COVID-19 communication materials to enhance COVID-19 testing in addition to vaccine confidence and uptake in underserved populations most severely affected by COVID-19 disease. The primary goal of this study is to maximize effective outreach, education, and communication through Community Health Workers to improve COVID-19 vaccine confidence and uptake in underserved and vulnerable communities.
Project Title:RI-Center for Clinical and Translational Science
ɲ:Brown University
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Summary:This project will enhance community engagement initiatives developed in RADx-UP Phase I to provide real-world data on vaccination, corroborated with patient-generated information, in underserved Hispanic/Latinx populations who face challenges due to many cultural, language, and social factors. The project will build on previous work to leverage the unique infrastructure of the 鶹ýӳ Exchange (HIE) in Rhode Island (RI), which connects data across the entire RI healthcare ecosystem, to obtain clinical data for most people receiving care in RI including SARS-CoV-2 test results and vaccinations.
Project Title:Bridging the evidence-to-practice gap: Evaluating practice facilitation as a strategy to accelerate translation of a systems-level adherence intervention into safety net practices
ɲ:New York University School of Medicine
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Summary:The project will use a storytelling, narrative-based approach, to promote healthy behaviors to address the challenges with COVID-19 vaccination acceptability and uptake; and tobreak down resistancetohealth-related messages.
Project Title:Expanding population-level interventions to help more low-income smokers quit
ɲ:Washington University
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Summary:The project will ask rent-relief helpline callers about COVID-19 vaccination and testing and evaluate strategies to help them with both. Initially, they will determine the COVID-19 vaccination rate of housing-unstable adults in St. Louis. The project will also evaluate the impact of targeted messages on unvaccinated callers’ intentions to get vaccinated, and to motivate in-home COVID-testing among those not interested in getting vaccinated.
Project Title:Increasing COVID-19 vaccine uptake through a patient navigation intervention among underserved populations
ɲ:San Diego State University
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Summary:This projectwill use a cluster randomizedcrossover trial to test mobile and home-based testing strategies for increasing testing uptakeamong contacts, referred high-risk friends and family, and the broader community.The project will cover over 40,000 individuals byutilizingexisting COVID-19 contact tracing and community partner infrastructure to reach individuals aged 12 and above exposed or at high-riskof COVID-19 exposure who may be less able to test.
Project Title:LA CaTS Supplement NOT-OD-21-101
ɲ:LSU Pennington Biomedical Research Center
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Summary:The Louisiana Clinical and Translational Science (LA CaTS) Center will lead a community-engaged research project with faith-based organizations to determine solutions to decrease vaccine hesitancy and improve testing rates in Louisiana underserved populations. The project will work with these communities to develop strategies to convey accurate, unbiased health information regarding COVID-19 vaccinations and testing to the community.
Project Title:Impact of COVID-19 Testing and Mitigation on Equitable Return-to-School in the Second Largest U.S. School District
ɲ:University of California, Los Angeles
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Summary:This project will show how COVID-19 surveillance testing influences secondary infection and school attendance and how it influences disparities in these outcomes associated with student characteristics, including poverty, race and ethnicity. The project will also study how surveillance testing influences disparities in parent perceptions of safety, decisions to return in-person, and daily attendance.
Project Title:Maximizing Child Health and Learning Potential: How to Promote A School Culture of Safety in the era of COVID-19
ɲ:University of Miami
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Summary:This project will seek to develop and test the feasibility of an urban school COVID-19 testing protocol and health education and vaccine confidence initiative.
Project Title:Back to ECE Safely with SAGE: Reducing COVID-19 Transmission in Hispanic and Low-income Preschoolers
ɲ:Arizona State University
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Summary:This projectwill rapidly provide critical information about a novel, FDA-authorized, low-burden saliva COVID-19 PCR test for use in young children. Additionally, the project willbe testing ability of the Sustainability via Active Garden Education (SAGE) Outdoor education program best practices to reduce transmission risk.
Project Title:Mobile Health-Targeted SARS-CoV-2 Testing and Community Interventions to Maximize Migrant Children's School Attendance During the COVID-19 Pandemic
ɲ:University of Nebraska Medical Center
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Summary:This project seeks to address critical gaps in public health mitigation and social responses faced by migrant children and their families living in rural Nebraska. The project will use mHealth-targeted, at-home salivary SARS-CoV-2 testing to identify cases of infection and employ mHealth social risk screening with linkage to public aid and community assistance for families suffering adverse social impacts related to COVID-19.
Project Title:Empowering Schools as Community Assets to Mitigate the Adverse Impacts of COVID-19
ɲ:University of Hawaii at Manoa
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Summary:The project will leverage a recently funded RADx-UP award to refine and disseminate an integrative testing-education strategy for a state-wide model for safe and sustainable school opening.
Project Title:Communities Fighting COVID!: Returning Our Kids Back to School Safely
ɲ:San Diego State University
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Summary:The project will evaluate at-home and on-site testing and will evaluate a family-based model of testing in Hispanic/Latino, Asian American, and socioeconomically disadvantaged populations.
Project Title:SCALE-UP Counts: A 鶹ýӳ Technology Approach to Increasing COVID-19 Testing in Elementary and Middle Schools Serving Disadvantaged Communities
ɲ:University of Utah
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Summary:This project will address key testing challenges in schools by building on collaborations with school districts and the Utah Department of Health. The project will implement and test a well-developed and scalable health information technology approach that delivers automated text messages regarding COVID-19 testing to students' parents.
Project Title:Social, Ethical, and Behavioral Factors in the Return to School among Underserved Communities in Maryland
ɲ:Johns Hopkins University
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Summary:The goal of this project is to examine social, ethical, and behavioral factors associated with parents of K-8 students’ willingness to return their children to in-person school, to remain in school, and their support for, and compliance with, COVID-19 testing and other mitigation strategies.
Project Title:Project Safe Schools: Re-opening schools SAFELY for Native American youth Awardee: Johns Hopkins University
ɲ:Johns Hopkins University
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Summary:The study will utilize a community-based participatory research process to understand implementation barriers to in-person school instruction and various testing strategies (e.g., students vs. teachers; screening vs. surveillance; at-home vs at-school) in schools that serve Native American students ages 3-16 years.
Project Title:ReSET: Restarting Safe Education and Testing for Children with Medical Complexity
ɲ:University of Wisconsin-Madison
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Summary:Thestudy will increase safe return to school for children with medical complexity and school personnel by establishing the feasibility of home and school-based testing strategies, identifying predictors of parents opting for in-person school, and establishing a consensus set of stakeholder priorities.
Project Title:COV-IDD: Testing for COVID-19 in high risk children with intellectual and developmental disabilities
ɲ:University of Rochester
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Summary:The study will utilize systems simulation modeling to develop an efficient virological and serological testing regimen, and to optimize tracing and isolation processes via in-school and mobile testing van, as well as address psychological barriers to inform maximal safe school participation for moderate-to-sever children with intellectual and developmental disabilities and school staff.
Project Title:WUIDDRC and KKI Safe Return to School
ɲ:Washington University
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Summary:Expanding upon an ongoing RADx-UP project of testing at the Special School District of St. Louis, the study will evaluate the impact of implementation strategies on the uptake of weekly surveillance testing in students with IDD and staff within the Kennedy Krieger Institute in Baltimore, and understand communication strategies to promote return to in-person instruction though parent survey and fuzzy cognitive mapping methodology.
Project Title:Support for Safe Return to in-Person School: COVID-19 Testing, Learning, and Consultation
ɲ:ICF Macro, Inc.
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Summary:Thestudy will develop and implement testing approaches in highly disadvantaged school setting. The study will augment the testing with tailored medical consultation and communication strategies and examine their benefit to in-person learning above and beyond testing. Finally, the study will disseminate learnings and tools to prepare other communities to develop tailored strategies that promote in-person learning.
Project Title:Using COVID-19 testing and risk communication strategies to accelerate students return to school
ɲ:University of Washington
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Summary:The study will test the effectiveness of a testing program on increasing Latino students' participation in onsite learning using community-based participatory research approach, as well as identify social, ethical and behavioral needs and resources to returning/maintaining onsite learning.
Project Title:Assessing Testing Strategies for Safe Return to K-12 Schools in an Underserved Population
ɲ:Washington University
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Summary:Within a predominantly Black/African American school community, the project will evaluate whether frequent screening testing will provide additional benefit, beyond current school-based mitigation strategies (including symptomatic testing), to prevent SARS-CoV-2 transmission and inform safe return to school. Further understanding of facilitators and barriers to testing will be evaluated regarding in-person school and vaccine hesitancy.
Project Title:SARS-CoV-2 Screening and Diagnostic testing for return to K-12 schools
ɲ:Duke University
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Summary:By leveraging the infrastructure and community partnerships formed through the ABC Science Collaborative, this project will assess the effectiveness of rapid surveillance testing in reducing within-school transmission and restoring trust among Black and Latino families to return to in-person school, as well as assess the uptake of school-based testing and time to safe school return after SARS-CoV-2 exposure.
Project Title:RADx-UP CDCC SAY YES COVID Test Study
ɲ:Duke University
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Summary:The study will evaluate a public health intervention combining frequent at-home testing with broad community engagement strategies, to reduce SARS-CoV-2 virus community transmission and conduct a study in a cohort of the population to understand the human behavior factors affecting viral testing.
Project Title:Predicting Diabetic Retinopathy from Risk Factor Data and Digital Retinal Images
Awardee: Charles R. Drew University of MedicineandScience
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Summary:This study will use a multidisciplinary, mixed-methods approach including unsupervised machine learning (ML) and qualitative interviews to systematically explore barriers and facilitators to COVID-19 testing among vulnerable populations.
Project Title:Reaching Communities through the Design of Information Visualizations (ReDIVis) Toolbox for Return of COVID-19 Results
Awardee: Columbia University Health Sciences
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Summary:This study will address health disparities by creating culturally congruent infographics to support comprehension of testing results, increase understanding, and approach next steps for patients in East Harlem, NY.
Project Title:Increasing Representation of Black Communities in SARS-Cov-2 Serosurveys by Understanding Barriers and Motivations for Participation
ɲ:Georgia State University
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Summary:This study will identify barriers and motivations to COVID-19 testing and vaccination among black populations, particularly as it relates to participation in existing serosurveys.
Project Title:Howard University Research Center for Minority Health and Health Disparities
ɲ:Howard University
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Summary:This study will develop strategies and best practices for COVID-19 interventions for Blacks/African Americans in the Washington D.C. metropolitan area.
Project Title:Exploring Barriers and Facilitators to Women Who Use Drugs (WWUD) Awareness, Acceptance and Uptake of COVID-19 Testing, the CARE study
Awardee: Johns Hopkins University
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Summary:This study will examine the behaviors, social, and structural factors correlated with testing and repeat testing among a cohort of women with substance abuse disorders in the Baltimore area.
Project Title:Continuous Traumatic Violence and the HIV Continuum of Care Outcomes Among BMSM
ɲ:Medical College of Wisconsin
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Summary:This study will characterize the convergence of three public health crises: the convergence of COVID-19, systemic racism, and community and police violence to understand how these may affect COVID-19 testing decisions among African Americans in the Chicago area.
Project Title:Bridging the Evidence-to-Practice Gap: Evaluating Practice Facilitation as a Strategy to Accelerate Translation of a Systems-Level Adherence Intervention into Safety Net Practices
ɲ:New York University School of Medicine
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Summary:This study will gain a comprehensive understanding of the multilevel factors that drive uptake of testing (and future vaccination) for COVID-19 and participation in follow-up care offered by safety-net health systems in Black and Latino/a patients.
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Awardee: University of California, San Francisco
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Summary:This study will evaluate a novel approach “Individual and Family-Oriented Responsive Messaging and Education” (INFORMED) that combines lay health worker education outreach with automated text messaging to facilitate COVID-19 testing uptake in Chinese, Hmong and Vietnamese Americans in urban and rural communities.
Project Title:Social, Ethical, and Behavioral Implications (SEBI) Research on COVID-19 Testing and Vaccine Uptake among Rural Latino Migrants in Southwest Florida
ɲ:University of South Florida
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Summary:This study will utilize the Hispanic Services Council (HSC) and promotoras de salud to develop population specific marketing strategies and community education regarding COVID-19 testing and vaccination to increase COVID-19 testing across a diverse set of communities.
Project Title:Expanding Population-Level Interventions to Help More Low-Income Smokers Quit
ɲ:Washington University
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Summary:This study will identify essential constructs for communication of testing to vulnerable populations through the 211-call center, integrating new knowledge into proven messaging tactics, and evaluating these new strategies and interventions.
Project Title:Assessing Vaccine Hesitancy and a Pharmacist Led Intervention Model to Increase COVID-19 Vaccine Uptake Among African Americans
Awardee: Xavier University of Louisiana
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Funding Opportunity Announcement:
Summary:This study will assess vaccine hesitancy and conduct a pharmacist-led intervention to increase COVID-19 vaccine uptake among African Americans.
Project Title:Leveraging Social Networks to Increase COVID-19 Testing Uptake: A Comparison of Credible Messenger and Chain Referral Recruitment Approaches
ɲ:New York State Psychiatric Institute
Project Number:
Funding Opportunity Announcement:
Summary:This study will focus on individuals that use opioids and other substances to improve testing within this New York City community.
Project Title:HIV/AIDS Clinical Trials Unit (CTU) COVID-19 RadX-UP Supplement
ɲ:University of North Carolina at Chapel Hill
Project Number:
Funding Opportunity Announcement:
Summary:This study will focus on rapidly improving testing in underserved Black and Hispanic/Latino communities in rural central North Carolina.
Project Title:Obesity Health Disparities Research Center (OHDRC) - COVID-19 Testing Model among Vulnerable Populations: From Community Engagement to Follow-Up
ɲ:University of Alabama at Birmingham
Project Number:
Funding Opportunity Announcement:
Summary:This study will implement a mobile, community-based testing model and evaluate its impact to improve testing and increase overall acceptance uptake.
Project Title:COVID-19 testing in Underserved and Vulnerable Populations Receiving Care in San Diego Community Health Centers
ɲ:University of California, San Diego
Project Number:
Funding Opportunity Announcement:
Summary:This study will develop, test, and evaluate a rapid and scalable capacity project to increase COVID-19 testing in San Diego, CA. The study will focus on at-risk, socioeconomically disadvantaged individuals, particularly vulnerable populations with comorbidities who are age 65 or older.
Project Title:Determinants and Outcomes of Nicotine Metabolite Ratio in HIV + Smokers
Awardee: University of Pennsylvania
Project Number:
Funding Opportunity Announcement:
Summary:This study will examine an intervention that draws parallels between COVID-19 and HIV/AIDS among Black and Hispanic/Latino populations in Philadelphia, PA. The approach will include secondary COVID-19 self-test distribution to individuals and their social networks.
Project Title:COVID-19 Testing and Linkage to Care with African American Church and Health Agency Partners
ɲ:University of Missouri, Kansas City
Project Number:
Funding Opportunity Announcement:
Summary:This study will examine a church-based intervention to increase rates of COVID-19 testing in a primarily African American community in Kansas City, MO.
Project Title:Optimization of a new adaptive intervention to increase COVID-19 testing among people at high risk in an urban community
ɲ:University of Illinois at Urbana-Champaign
Project Number:
Funding Opportunity Announcement:
Summary:This study will define the process by which medical or socially vulnerable people seek out COVID-19 tests and results.
Project Title:Safety, Testing/Transmission, and Outcomes in Pregnancy with COVID-19 (STOP-COVID-19 study)
ɲ:Washington University
Project Number:
Funding Opportunity Announcement:
Summary:In this study, researchers will perform antibody testing to determine how asymptomatic COVID-19 infection in pregnancy increases risk of adverse pregnancy outcomes.
Project Title:Epidemiologic Intelligence Network (EpI-Net) to Promote COVID-19 Testing and Prevention Practices Among Socially Vulnerable Communities in Puerto Rico
Awardee: Ponce School of Medicine
Project Number:
Funding Opportunity Announcement:
Summary:This study will evaluate the impact of an epidemic intelligence (EpI-Net) community-based intervention aimed at increasing COVID-19 testing uptake and prevention practices among socially vulnerable populations in Puerto Rico.
Project Title:Prevention of Substance Use in At-risk Students: A Family-centered Web Program
ɲ:University of Oregon
Project Number:
Funding Opportunity Announcement:
Summary:This study will use community-based participatory approaches to develop, implement, and evaluate a COVID-19 testing program offered through syringe services programs, a natural point of care for persons who inject drugs.
Project Title:Connecting our Neighborhoods Need for Enhanced and Coordinated Testing to Achieve Equity: CoNNECT to Achieve Equality
ɲ:University of Arkansas for Medical Sciences
Project Number:
Funding Opportunity Announcement:
Summary:This study will focus on increasing COVID-19 testing among Latino/a and Native Hawaiian/Pacific Islander communities in two counties in Northwest Arkansas.
Project Title:Center for American Indian and Rural Health Equity
Awardee: Montana State University, Bozeman
Project Number:
Funding Opportunity Announcement:
Summary:This study will use pragmatic randomized testing to evaluate home based testing through comparing community health workers with mail in at-home testing and their related feasibilities.
Project Title:Alive Church Network: Increasing COVID-19 Testing in Chicago’s African American Testing Deserts
ɲ:Rush University Medical Center
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Funding Opportunity Announcement:
Summary:This study will leverage an existing coalition of African American pastors and academics in Chicago to conduct an evaluation for COVID-19 testing in areas with limited testing.
Project Title:Investigating the Effectiveness of COVID-19 Testing Choices, Community Engagement, and Culturally-Embedded mHealth Literacy Delivery in a Medically-Underserved, Community-Based Sample
ɲ:University of Illinois at Chicago
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Funding Opportunity Announcement:
Summary:This study will provide central community-based surveillance approaches via smartphone apps for African Americans and Hispanic communities in the broader Chicago area.
Project Title:Louisiana Clinical and Translational Science Center
ɲ:Louisiana State University Pennington Biomedical Research Center
Project Number:
Funding Opportunity Announcement:
Summary:This study will determine testing rates for multiple testing sites and community-driven approaches for increasing uptake in underserved Black urban communities in Louisiana.
Project Title:Keeping Rural Minority Essential Workplaces Open Safely During The COVID-19 Pandemic: The Role of Frequent Point-of-Care Molecular Workplace Surveillance for Miners
ɲ:University of New Mexico Health Sciences Center
Project Number:
Funding Opportunity Announcement:
Summary:This study will focus on workplace surveillance and monitoring to increase the acceptance rate of testing and prevent COVID-19 infections among miners in the Southwest.
Project Title:Implementing Community-based Approaches to Increase SARS-CoV-2 Testing among an Underserved and Vulnerable Hispanic Population
ɲ:University of Texas at El Paso
Project Number:
Funding Opportunity Announcement:
Summary:This study will integrate academic, non-profit, business, and public partners in El Paso, TX, to reduce SARS-CoV-2 testing deficiencies through providing testing information, navigation strategies, and implementing local pop-up testing sites. Researchers will implement strategies that target the cultural, social, and behavioral factors characteristic of this population.
Project Title:Puipuia le Ola: Increasing Reach and Uptake of COVID-19 Testing Among Pacific Islanders in Hawaii and Guam
ɲ:University of Hawaii at Manoa
Project Number:
Funding Opportunity Announcement:
Summary:This study will develop and evaluate culturally tailored community interventions for outreach COVID-19 testing amongPacific Islanders in Hawaii and Guam.
Project Title:Building Resilience and Vital Equity (BRAVE) - Increasing COVID-19 Testing in American Indians
ɲ:North Carolina Central University
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Funding Opportunity Announcement:
Summary:This study will evaluate the impact of work to increase testing uptake for American Indians in North Carolina.
Project Title: Prevention Research Center: Parenting Among Women Who Are Opioid Users
Awardee: University of Oregon
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Funding Opportunity Announcement:
Summary: This project addresses a community-tailored outreach program for the Latina population within six counties in Oregon. It will examine the rural-urban distinction, with a sensitivity to geographical approach that will be imperative for later scaling efforts.
Project Title: Clinical and Translational Science Award
Awardee: Medical College of Wisconsin
Project Number:
Funding Opportunity Announcement:
Summary: This project will perform community-engaged research using randomized COVID-19 tests among vulnerable populations in Milwaukee County, Wisconsin. The study will focus on understanding COVID infection and progression rates and how they vary with patient characteristics.
Project Title: Protecting Native Families from COVID-19: RADx Initiative
Awardee: Johns Hopkins University
Project Number:
Funding Opportunity Announcement:
Summary: Thisstudy will address high rates of morbidity and mortality due to COVID19 among American Indian (AI) and Navajo Nation (NN) communities in the US. The goal of this study is to increase and speed up the testing among those with symptoms and improve adherence to recommended strategies.
Project Title: Improved Testing for COVID-19 in Skilled Nursing Facilities: IMPACT-C
Awardee: Brown University
Project Number:
Funding Opportunity Announcement:
Summary: This project will leverage an existing National Institute of Aging Imbedded Pragmatic Alzheimer’s Disease/Alzheimer’s Disease Related Dementias Clinical Trials (IMPACT) Collaboratory to establish IMPACT-COVID-19, a collaborative that aims to develop and evaluate SARS-CoV-2 testing strategies in highly-vulnerable, skilled nursing facilities’ (SNF) residents and workers.
Project Title: Community Network Driven COVID-19 Testing of Vulnerable Populations in the Central US
Awardee: University of Chicago
Project Number:
Funding Opportunity Announcement:
Summary: This project will evaluate the impact of an evidence-based Social Network Testing Strategy (SNS) combined with community developed COVID-19 public health messages (SNS+).
Project Title: COVID-19 Testing and Prevention in Correctional Settings
Awardee: Yale University
Project Number:
Funding Opportunity Announcement:
Summary: This study will work with diverse correctional facilities across MN, RI, WA, and FL to characterize the incidence of COVID-19 disease progression and related outcomes. The goal is to identify barriers and facilitators to develop strategies to improve testing in these underserved populations.
Project Title: The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve Health
Awardee: Ohio State University
Project Number:
Funding Opportunity Announcement:
Summary: This study will address and reduce the disparities in COVID-19 education, testing, contact testing, follow-up and treatment among minority, underserved, vulnerablepopulations in 12 selected counties in Ohio.
Project Title: Community-Engaged Research on COVID-19 Testing in the US Territories
Awardee: Yale University
Project Number:
Funding Opportunity Announcement:
Summary: This study will enhance COVID-19 testing and implementation using community-engaged research in the Caribbean Islands, Puerto Rico (PR) and the U.S. Virgin Islands (USVI), both with high proportions of high-risk populations, including Black and Latino/Latina populations.
Project Title: RADx-UP NARCH Supplement: A Cherokee Nation Community-Driven Program for Testing and Contact Tracing (Cherokee PROTECT)
Awardee: Cherokee Nation
Project Number:
Funding Opportunity Announcement:
Summary: This study will enhance understanding of COVID-19 within the significantly and disproportionally impacted residents of Cherokee Nation. The researchers will perform rapid point-of-care testing, antibody testing, and contact tracing, and will develop educational materials for the community. Rapid data analysis will be used to nimbly move testing sites to areas of need.
Project Title: Community Driven Approach to Mitigate COVID 19 Disparities in Hawaii's Vulnerable Populations
Awardee: University of Hawaii at Manoa
Project Number:
Funding Opportunity Announcement:
Summary: This study will close testing gaps and eliminate COVID-19 disparities among Native Hawaiian and other Pacific Islanders (NHPI) and Filipinos living in rural and underserved communities in Hawaii by integrating innovative SARS-CoV-2 testing capacity with novel community-specific messaging and education.
Project Title: Leveraging Bio-Cultural Mechanisms to Maximize the Impact of Multi-Level Preventable Disease Interventions with Southwest Populations
Awardee: Arizona State University-Tempe Campus
Project Number:
Funding Opportunity Announcement:
Summary: This study will perform targeted SARS-CoV-2 testing within defined testing deserts in Arizona and will compare a subset of affected individuals who undergo the proposed testing and educational protocol with those who receive the same testing through standard systems available in the state.
Project Title: Monitoring COVID-19 and Building Capacity with Northern Plains Tribes and the Future of Pandemics
Awardee: Stanford University
Project Number:
Funding Opportunity Announcement:
Summary: This study will upgrade and sustainlocal capacity at the Native BioData Consortium (NBDC) with training and development ofPersonal Protective Equipment (PPE) and Lab Protocols to improve COVID-19 testing and outcomes for Tribal populations by creating an improved diagnostics lab/local data resource and by testing the use of wearables on early diseases detection.
Project Title: ORALE COVID-19: Organizaciones para Reducir, Avanzar y Lograr Equidad contra el COVID-19 (Organizations to Reduce, and to Advance, and Lead for Equity against COVID-19)
Awardee: University of California,Davis
Project Number:
Funding Opportunity Announcement:
Summary: This study will understand and overcome the barriers to testing for SARS-CoV2 in Latino/Latina populations in California's central valley through interventions to increase testing.
Project Title: Community-Academic Partnership to Address COVID-19 Among Utah Community Health Centers
Awardee: University of Utah
Project Number:
Funding Opportunity Announcement:
Summary: This study will employ 39 community health centers across the state to help underrepresented individuals using three pathological, multilevel interventions to increase screening and testing uptake. This technology-based strategy will employ the use of EHR record analysis and text screening to identify high-risk individuals and connect them to patient navigators.
Project Title: Community-Engaged Research on COVID-19 Testing Among Underserved and/or Vulnerable Populations
Awardee: Florida International University
Project Number:
Funding Opportunity Announcement:
Summary: This study will improve testing uptake in Miami Dade county through a community-based approach that includes a community advisory board and community surveys to determine the best approach to testing and receptiveness of different sample collection approaches.
Project Title: The Johns Hopkins Center for AIDS Research (JHU CFAR) RADx-UP
Awardee: Johns Hopkins University
Project Number:
Funding Opportunity Announcement:
Summary: This study will perform a cluster-randomized trial comparing the effectiveness of three testing strategies to address COVID-19 testing disparities among African American, Latino/Latina, and socioeconomically disadvantaged populations in Baltimore.
Project Title: Implementation Science Center in Cancer Control Equity: A Competitive Revision to Accelerate COVID Testing in Vulnerable Communities
Awardee: Harvard School of Public Health
Project Number:
Funding Opportunity Announcement:
Summary: This study will accelerate COVID-19 testing in nine Massachusetts communities and six community health centers through a community-engaged approach. The study will create and implement an infrastructure to improve testing and evaluate its impact and further integrate with community partners, outreach training to residents, and provide clinical training to community health clinicpersonnel.
Project Title: Communities Fighting COVID!
Awardee: San Diego State University
Project Number:
Funding Opportunity Announcement:
Summary: This study will use community health workersfor outreach to underserved populations (Latino/Latina, African American, Filipino, and immigrant communities) in the San Diego area to facilitate COVID-19 testing.
Project Title: A Nurse-Community Health Worker-Family Partnership Model to Increase COVID-19 Testing in Urban Underserved and Vulnerable Communities
Awardee: New York University
Project Number:
Funding Opportunity Announcement:
Summary: The study will leverage the investigators’ longstanding community partners in Mott Haven in South Bronx, NY, and existing infrastructure to increase COVID-19 screening and access to results.
Project Title: A Dynamic COVID-19 Community-Engaged Testing Strategy in Alabama (COVID COMET AL)
Awardee: University of Alabama at Birmingham
Project Number:
Funding Opportunity Announcement:
Summary: This study will evaluate the implementation of a rapid scale-up SARS-CoV-2 testing strategy (ADAPT framework including Assessment, Preparation, and Implementation Phases) in Alabama with goal of maximizing the outreach to underserved communities disproportionately impacted by COVID-19.
Project Title: Harnessing Technological Innovation and Community-Engaged Implementation Science to Optimize COVID-19 Testing for Women and Children in Underserved Communities
Awardee: University of California, San Diego
Project Number:
Funding Opportunity Announcement:
Summary: This study seeks to maximize COVID-19 testing amongst pregnant women and children in an area of the San Diego district near the United States-Mexico border that has been noted to have the highest incidence of COVID-19.
Project Title: WUIDDRC Supplement-Supporting the Health and Well-being of Children with Intellectual and Developmental Disability during COVID-19 Pandemic
Awardee: Washington University
Project Number:
Funding Opportunity Announcement:
Summary: This study will determine the best implementation strategies to maximize the use of an FDA-approved diagnostic test for vulnerable children with intellectual and developmental disabilities (IDD) in a school setting at Washington University.
Project Title: New Jersey Alliance for Clinical and Translational Science: NJ ACTS
Awardee: Rutgers Biomedical and Health Sciences
Project Number:
Funding Opportunity Announcement:
Summary: This study proposes COVID-19 screening programs serving lower-income health care workers and support staff. The study aims to catalyze COVID-19 testing in their households, extended families/networks, and ultimately, amplify community-based testing in vulnerable, underserved populations among low-income, Black and Latino/Latina minority communities in New Jersey counties.
Project Title: Rapid Optimization of COVID-19 Testing for People Affected by Diabetes
Awardee: Emory University
Project Number:
Funding Opportunity Announcement:
Summary: This study will optimize testing for minority populations affected by diabetes and associated comorbidities including pre-diabetes and obesity. An iterative testing strategy will be implemented at federally qualified health centersthat provide care for uninsured and at-risk individuals and community engagement techniques.
Project Title: Center for Clinical and Translational Sciences (CCTS)
Awardee: University of Texas Health Science Center at Houston
Project Number:
Funding Opportunity Announcement:
Summary: This study will identify dynamic disease hotspots and testing deserts in racially diverse regions of South (Houston/Harris County) and Northeast Texas.
Project Title: Developing Novel Strategies to Increase COVID-19 Testing among Underserved and Vulnerable Populations in West Virginia through Community and State Partnerships
Awardee: West Virginia University
Project Number:
Funding Opportunity Announcement:
Summary: This study proposes to address COVID-19 testing disparities by enhancing COVID-19 testing among rural primary care offices located across West Virginia, intensifying COVID-19 testing through mobile vans in areas forecasted to experience a near-term increase in COVID-19 incidence, and further increasing COVID-19 testing in Black/African American communities through dedicated mobile van and home testing.
Project Title: RADx-UP: Improving the Response of Local Urban and Rural Communities to Disparities in COVID-19 Testing
Awardee: University of Kansas Medical Center
Project Number:
Funding Opportunity Announcement:
Summary: This study proposes to examine the effectiveness of a Learning Collaborative's effort that helps local community organizations address disparities in COVID-19 testing by building “Local Health Equity Action Teams” in 10 disproportionally COVID-19-affected counties.
Project Title: Community Organizations for Natives: COVID-19 Epidemiology, Research, Testing, and Services (CONCERTS)
Awardee: Washington State University
Project Number:
Funding Opportunity Announcement:
Summary: This study focuses on satellite centers that partner with sixgeographically contiguous Urban Indian Health Programs (UIHPs) across the United States to launch studies under Community Organizations for Natives: COVID-19 Epidemiology, Research, Testing, and Services (CONCERTS). The overarching goal is to remove barriers and increase SARS-CoV-2 testing among urban American Indian/Alaska Native populations by offering an array of testing options that cover a wide geographical area.
Project Title: Oklahoma Shared Clinical and Translational Resources
Awardee: University of Oklahoma Health Science Center
Project Number:
Funding Opportunity Announcement:
Summary: This studywill leverage existing community partnerships to help overcome the lack of robust public health infrastructure and healthcare in Oklahoma to address gaps in COVID-19 testing in rural populations.
Project Title: Collaborative Community Networks to Optimize Implementation of Low Barrier COVID-19 Testing Efforts among Diverse Latinx Populations in Northern California
Awardee: University of California, San Francisco
Project Number:
Funding Opportunity Announcement:
Summary: Thisstudy aims to implement and evaluate community-engaged approaches to improving access and uptake of COVID-19 testing in Latino/a communities in Northern California and understand local epidemiology and factors driving the stark ethnic disparities observed in COVID-19 case rates.
Project Title: Evaluation of Smoke-Free Housing Policy Impacts on Tobacco Smoke Exposure and Health Outcomes
Awardee: New York University School of Medicine
Project Number:
Funding Opportunity Announcement:
Summary: This proposal aims to increase access and determine community-informed preferences for testing using a community health worker-facilitated comparative effectiveness study in the New York Housing Authority.
Project Title: Rhode Island Center for Clinical and Translational Science
Awardee: Brown University
Project Number:
Funding Opportunity Announcement:
Summary: This projectis targeted to increase testing in the Rhode Island Latino/Latina community through partnerships with community clinics.
Project Title: Juntos (Together): A community led approach to enhance to COVID-19 testing among vulnerable Latinos
Awardee: Johns Hopkins University
Project Number:
Funding Opportunity Announcement:
Summary: This proposal looks to increase access and uptake of testing in the Latino/Latina community in Baltimore using a combination of social media strategies and community navigators to connect individuals to care. This testing campaign will center on a bilingual website that addresses community concerns and allows identification of testing sites.
Project Title: LITE CONNECT: Addressing testing gaps and epidemiologic disparities of COVID-19 among transgender people in the United States
Awardee: Johns Hopkins University
Project Number:
Funding Opportunity Announcement:
Summary: This project aims to better understand barriers and facilitators of testing in the transgender community using an internet-based approach and a home testing strategy.
Project Title: Advancing Palliative Care in Northern Plains American Indians
Awardee: Massachusetts General Hospital
Project Number:
Funding Opportunity Announcement:
Summary: This research will perform a phased study of three Lakota tribes in South Dakota to address attitudes and access to testing.
Project Title: Use of Behavioral Economics in Repeat SARS-CoV-2 Antibody Testing in Disadvantaged Communities
Awardee: University of Southern California
Project Number:
Funding Opportunity Announcement:
Summary: This study is looking to investigate the social and behavioral determinants of COVID-19 testing in the Hispanic population in Los Angeles.
Project Title: Role of Alcohol Disparities in HIV Risk among Sexual Minority Youth
Awardee: Northwestern University at Chicago
Project Number:
Funding Opportunity Announcement:
Summary: This study will analyze COVID-19 testing among marginalized and understudied racial/ethnic minority and sexual and gender minorityyouth and young adults by utilizing a national online survey and qualitative interviews to determine what factors influence testing attitudes with the goal of developing social marketing and text message health messaging interventions.
Project Title: Social and Behavioral Implications for COVID-19 Testing in Delaware's Underrepresented Communities
Awardee: Delaware State University
Project Number:
Funding Opportunity Announcement:
Summary: This study will use retrospective data from the 2010 census and a Johns Hopkins University COVID-19 survey from the PHenX and DR2 repository to look at patterns of COVID-19 testing.
Project Title: Addressing Low-Income Housing Resident Mistrust in COVID-19 Guidance
Awardee: Eastern Virginia Medical School
Project Number:
Funding Opportunity Announcement:
Summary: This study will address distrust among low income housing residents towards public housing authorities (PHA) and determine how this impacts guidance and COVID-19 recommendations.
Project Title: RADx-UP CDCC
Awardee: Duke University
Project Number:
Funding Opportunity Announcement:
Summary: This study will bring together an interdisciplinary team comprising principal investigators with complementary expertise in clinical trial management, community engagement, data science and clinical research informatics to create a community-focused coordination and data collection centerfor RADx-UP.
RADx Tech/ATP
Project Title: A Rapid, Accurate, Disposable Molecular Diagnostic to detect SARS-CoV-2
Awardee:Visby Medical
Description:A palm-sized, single-use RT-PCR device that detects viral RNA with highly accurate results at the point-of-care in 30 minutes. The device was designed to be used by a person with minimal skills. This novel, versatile technology platform can also be adapted to provide simple, rapid tests for other diseases such as chlamydia, gonorrhea, and influenza.
Budget:$9,623,789
Additional Information:
Project Title:SARS-CoV-2 lab test accuracy within reach of every American with Liberty16 mobile real time PCR
Awardee:Ubiquitome
Description:A battery-operated, mobile RT-PCR device that detects viral RNA with high accuracy in 40 minutes and reports results via its proprietary iPhone app. It offers high throughput and could be much lower cost than lab-based RT-PCR tests. The device is targeted for use in rural and metropolitan hospitals and mobile labs.
Budget:$2,460,000
Additional Information:
Project Title: Massively parallel centralized and decentralized ultrafast COVID-19 infectiousness testing
Awardee:Flambeau Diagnostics
Description: A lab module that can be deployed in a mobile van to screen asymptomatic individuals to detect SARS-CoV-2at low viral levelsin saliva samples, returning results in as little as one hour. The system can serve employers, schools, and underserved populations. It uses newextractiontechnology to purify and concentrate viral RNA reliably and quickly.
Budget:$12,000,000
Additional Information:
Project Title:Ultra-Sensitive Immunoassay Test for Quantitation of SARS-CoV-2 Antigen
Awardee:Quanterix
Description:A laboratory antigen test with ultra-sensitive single-molecule immunoassay technology to enable detection from a variety of sample types including nasopharyngeal, saliva or self-acquired blood from a finger prick. Sample collection, transport, and processing will occur within 24-48 hours using existing sample collection logistics infrastructure through a network of centralized labs.
Budget:$18,200,000
Additional Information:
Project Title: A smartphone-based at-home self-test for rapid SARS-CoV-2 antigen detection from respiratory samples
Awardee:Luminostics, Inc.
Description:A rapid, smartphone-readout, antigen immunoassay that uses glow-in-the-dark nanomaterials to sensitively and specifically detect SARS-CoV-2 from shallow nasal swabs in 30 minutes or less, first for point-of-care use and later for home use.
Budget:$26,120,000
Additional Information:
Project Title:An innovative point-of-care COVID 19 antigen test for the direct detection of the SARS-CoV-2 virus
Awardee:Ellume USA LLC
Description: Two unique test cartridges contain a single-use, digital fluorescent immunoassay antigen test that returns accurate results in 15 minutes or less.One cartridge testing nasal swabs can be read out on two platforms by healthcare professionals, at the point of care or in laboratory settings for higher throughput. A second cartridge is being developed for home use with a self-administered nasal swab.
Budget:$29,950,000
Additional Information:
Project Title: Rapid Expansion of Existing Framework for Deploying Large-Scale COVID-19 RT-PCR Testing Platforms and Distributing Capacities
Awardee: Sonic Healthcare USA
Description: Expanded scope and expedited timeline of a framework for large-scale COVID-19 RT-PCR testing platforms and distribution capacity. With a network of regional testing hubs, the company can simultaneously deploy multiple test platforms and methodologies. They will continue to add capacity to reach about 166,000 samples tested per day with new high-throughput technology.
Budget: $20,799,000
Additional Information:
Project Title:PathGroup SARS-CoV-2 High Throughput Laboratory Capacity Scale-Up
Awardee: PathGroup
Description: Uses Roche 6800 and Hologic Panther instruments to currently process about 10,000 COVID-19 RNA tests a day. Has infrastructure in place in 20 states throughout the U.S. Southeast and Midwest. They have partnered with ThermoFisher, LGC and Illumina to add additional instrumentation and automation to increase the daily number of COVID-19 tests performed to 80,000 by December 2020.
Budget:$20,750,000
Additional Information:
Project Title: Illumina MegaLab: A Massively Scaled Next Generation Sequencing Lab For COVID-19 Testing in the U.S.
Awardee:Illumina, Inc.
Description: Automated sample processing and next-generation sequencing technology for COVID-19 testing that will be scaled up. Its high-throughput capacity can be expanded to 48,000 tests per day. Upon receipt of samples at the laboratory, the company can process results for the Illumina COVIDSeq test within 24 hours.
Budget: $12,398,342
Additional Information:
Project Title:Nanotrap manufacturing scale-up to meet rapidly expanding needs for direct SARS-CoV-2 detection in high-throughput settings
Awardee:Ceres Nanosciences, Inc.
Description: A sample prep method using Nanotrap particles that extracts and concentrates viral material to reduce processing time and improve sensitivity. This method can be used on a variety of testing platforms, from point-of-care systems to high-throughput laboratory processes, to improve speed and performance by 2- to 10-fold.
Budget:$6,574,000
Additional Information:
Project Title:Scaling the Broad Institute RT-PCR testing process to 100k+ tests/day
Awardee:Broad Institute
Description: A high-throughput RT-PCR COVID-19 viral test using specimens from nasal swabs that will be scaled up. Its facility already performs tests for more than 530 regional hospitals, nursing homes, shelters, community health centers, senior living facilities and at state and city collection sites in vulnerable communities. The award is helping to increase from 25,000 to 100,000 tests per day.
Budget:$14,584,482
Additional Information:
Project Title: Aegis Sciences Rapid Development of SARS-CoV-2 Test Capacity
Awardee:Aegis Sciences
Description: A novel coronavirus nucleic acid detection kit and distribution system for high through-put testing that uses nasal and oral swab samples. Has recently quadrupledcapacity to 15,000 samples per day and will soon reach 60,000 samples per day. After receipt of samples, these tests will return results in 24 hours or less on average.
Budget:$6,582,976
Additional Information:
Project Title:Accurate, Sensitive & Affordable POC and At Home Testing Device
Awardee:MicroGEM International
Description: A portable, point-of-care device that detects SARS-CoV-2 in saliva samples using RT-PCR in 15 minutes. The test uses a microfluidic cartridge with the potential for simultaneous detection of multiple pathogens such as influenza.
Budget:$40,928,479
Additional Information:
Project Title:Maxim SARS-CoV-2 Antigen Rapid Test
Awardee:Maxim Biomedical, Inc.
Description:A single-use, lateral-flow test strip immunoassay that can provide results in 15 minutes or less. With the improved workflow, the assay can be performed without an instrument for reading and does not require any specialized equipment.
Budget:$5,253,450
Additional Information:
Project Title:Deployment of a rapid, point of use technology for COVID-19 testing
Awardee:MatMaCorp
Description: A portable mini-lab that can rapidly perform multiple RT-PCR assays in a single platform. This technology can be used with multiple sources of reagents and is targeted for community hospitals and clinics in underserved, rural populations.
Budget:$1,390,000
Additional Information:
Project Title: Rapid Manufacturing Scale-up for Compact Point-of-Care EUA SARS-CoV-2 RT-PCR Test
Awardee: Mesa Biotech, Inc.
Description: This test employs a hand-held RT-PCR device and a compact, single-use cartridge that detects viral RNA at the point of care. Results can be read from the removable cartridge in 30 minutes.
Budget: $18,536,704
Additional Information:
Project Title: Talis-One/Talis HT: Highly Scalable SARS-CoV-2 RNA Detection in Minutes, from POC to Hundred-per-Hour Throughput
Awardee: Talis Biomedical Corp.
Description: This point of care test is a multiplexed cartridge used with the compact Talis One instrument. The test detects SARS-CoV-2 through isothermal amplification of viral RNA and an optical detection system, returning a result in under 30 minutes.
Budget: $25,400,000
Additional Information:
Project Title: Manufacturing Capacity Scale-Up for Sofia SARS Antigen and Sofia Influenza A+B/SARS FIAs
Awardee: Quidel Corp.
Description: This test kit, a lateral flow immunoassay, is used with Sofia and Sofia 2 Analyzers in point of care settings, such as a doctor’s office or pharmacy. There are currently thousands of Quidel analyzers in place across the U.S. and HHS has identified this technology for nursing homes. The Analyzers give electronic results within 15 minutes.
Budget: $71,000,000
Additional Information:
Project Title: Detection of SARS-CoV-2 with the CRISPR-based DETECTR platform
Awardee: Mammoth Biosciences
Description: This assay uses CRISPR technology, which provides a simpler workflow and significantly faster turnaround time compared to conventional laboratory PCR tests. This high-throughput solution can result in a multi-fold increase in testing capacity in commercial laboratories.
Budget: $23,081,269
Additional Information:
Project Title: Scaling to Massive Throughput: 4.5 Million SARS-CoV-2 Tests per Day
Awardee: Fluidigm Corp.
Description: Each BioMark HD microfluidics platform has the capacity to process thousands of SARS-CoV-2 PCR tests per day with a primary focus on saliva samples. With many existing Fluidigm instruments in clinical and research labs throughout the U.S., scale up and deployment of their advanced integrated fluidic chips can provide tens to hundreds of thousands of new tests per day in fall 2020.
Budget: $36,834,000
Additional Information:
Project Title: Reproducible clinical test system for 1 million daily SARS-CoV-2 tests using amplicon sequencing
Awardee: Helix OpCo, LLC
Description: Helix will ship standardized kits in bulk for the collection of nasal swabs to public health departments, health care systems, employers and other customers to collect tens of thousands of samples and processed within 24-48 hours using sophisticated automation processes and next generation sequencing technologies. Expected to process up to 50,000 samples/day by Sept. 2020 and 100,000/day by year’s end.
Budget: $33,421,500
Additional Information:
Project Title: RADx-ATP Concentric: A High-Throughput Next Generation Sequencing-based Molecular Diagnostic for SARS-CoV-2
Awardee: Ginkgo Bioworks
Description: Ginkgo is scaling up by using significant automation and next-generation sequencing technologies to process tens of thousands of tests at once. Working with universities, schools, public or private companies, and local communities, they will provide end-to-end sample collection and report results within 24-48 hours. Expected to scale up to 50,000 tests/day in Sept. 2020 and 100,000/day by year’s end.
Budget: $40,473,832
Additional Information:
RADx Radical (RADx-rad)
Project Title:A Confectionary-based Screening Tool for Assessing Chemosensory Loss in COVID-19 Patients
Awardee: Ohio State University
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop, validate, and deploy a novel test that uses hard candy to independently assess smell and taste function in individuals who are at high risk for contracting COVID-19.
Project Title:Bioinformatics Framework for Wastewater-based Surveillance of Infectious Diseases
Awardee: Arizona State University
Project Number:
Funding Opportunity Announcement:
Summary:This project will implement and evaluate a near real-time wastewater-based epidemiology (WBE) framework for SARS-CoV-2 for communities throughout the U.S. to provide a snapshot of community spread and advanced knowledge of future trends in morbidity and mortality that will allow for targeted public health protection measures.
Project Title:Nanobody-based Electrochemical Biosensor for Real-Time Detection of Aerosolized SARS-CoV-2
ɲ:Washington University
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop an electrochemical biosensor in two detection devices, 1) a diagnostic breathalyzer for instant detection of SARS-CoV-2 and 2) an airborne detector for real-time, continuous surveillance of a large space.
Project Title:Detection and Automatic Privacy-Protected Contact Tracing System Designed for COVID-19
Awardee: Louisiana State Univ A&M Col Baton Rouge
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop a designer DNA nanostructure-based capture probe that harbors a macromolecular “net” whose vertices precisely match the intra- and inter-spatial pattern of SARS-CoV-2 trimeric spike glycoprotein clusters and integrates a netshaped array of SARS-CoV-2 spike specific-targeting aptamers.
Project Title:Rolosense: An Innovative Platform for Automatic Mobile Phone Readout of Active SARS-CoV-2 Particles
ɲ:Emory University
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop a novel platform technology for automatic surveillance and tracing of airborne SARS-CoV-2 virus particles in real-time. The centerpiece of this proposal is the “Rolosense” technology which leverages a DNA micromotor as the virus sensing and transduction material that can be detected by a conventional smart phone camera.
Project Title:Minimal False-alarm Touch-based Detection of SARS-Cov-2 Virus Particles using Poly-aptamers
Awardee: General Electric Global Research Center
Project Number:
Funding Opportunity Announcement:
Summary:This project will build a touch-screen sensor array to directly capture, detect, and identify model SARS-CoV-2 virus particles with minimal false alarms. The proposed solution is based on several innovations driven by eliminating a need for a dedicated sampling step and solving the problems of detection and reliable selective recognition of virus particles, performing detection/recognition operation in a two-dimensional format of biosensors.
Project Title:Touchscreen-compatible, Real-Time Electrochemical Sensing of SARS-CoV-2
ɲ:University of Washington
Project Number:
Funding Opportunity Announcement:
Summary:This project will integrate aptamer-based biosensing of SARS-CoV-2 into a touchscreen device. The main objectives are to 1) engineer conformation switching aptamers for electrochemical sensing of SARS-CoV-2 binding, 2) develop nanogap capacitive sensors as a uniquely complementary approach to capacitive touchscreen technology and 3) build and test an integrated biosensor and touchscreen array that can detect SARSCoV-2 from patient samples.
Project Title:Development of an Automated Diagnostic Platform for SARS-CoV-2 Monitoring in Vulnerable Areas
ɲ:Clemson University
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop a label-free multiplexing platform for rapid detection of SARS-CoV-2 and its mutants in saliva. The proposed system will integrate signals from different biorecognition elements, with aptamer, antibody, and ACE2 immobilized onto laser inscribed graphene electrodes.
Project Title:Development and Proof-of-Concept Implementation of the South Florida Miami RADx-rad SARS-CoV-2 Wastewater-Based Surveillance Infrastructure
Awardee: University of Miami Coral Gables
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Funding Opportunity Announcement:
Summary:This project will develop, implement, and demonstrate effective and predictive wastewater surveillance by optimizing sampling, concentration, and detection strategies. The objectives will be addressed through three aims, including data Standardization, wastewater characterization, and Integration with Human Health Surveillance.
Project Title:Wastewater Analysis of SARS CoV-2 in Tribal Communities
Awardee: Arizona State University-Tempe
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Funding Opportunity Announcement:
Summary:This project proposes wastewater-based epidemiology as a non-invasive, culturally appropriate biomonitoring strategy for adoption and implementation by Tribal communities as a health surveillance tool. The project aims to measure coronavirus in wastewater across U.S. reservations using established RT-qPCR techniques and a novel protein quantification method, and sequences viral RNA extracts to assess SARS- CoV-2 variants in Tribal communities.
Project Title:Improved Scalability, Sensitivity, and Interpretability of Pathogen Detection, Including SARS-CoV-2, in Wastewater using High-Throughput, Highly Multiplexed Digital Array PCR Technology
ɲ:University of North Carolina, Chapel Hill
Project Number:
Funding Opportunity Announcement:
Summary:This project proposes highly multiplexed digital PCR assays on wastewater collected from multiple diverse geographical regions that will be comprehensive, rapid, low cost, and quantitative for monitoring the circulation of disease. The assay system will be able to address novel pathogens by allowing rapid aggregation of genetic tests for these new targets.
Project Title:Wastewater Assessment for Coronavirus in Kentucky: Implementing Enhanced Surveillance Technology
Awardee: University of Kentucky
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop next generation wastewater assessment loop-mediated isothermal amplification technology and implement and validate the next generation assay at congregate living facilities side-by-side with conventional wastewater surveillance. This will include wastewater treatment plant operators, watershed watch citizen scientists, and school science teachers to test wastewater in Appalachian Kentucky communities and schools using the assay, whose results are validated in lab.
Project Title:Wastewater Detection of COVID-19
Awardee: Missouri State Dept/ Health & Senior Services
Project Number:
Funding Opportunity Announcement:
Summary:This project will monitor congregate facilities to define per-patient contribution and longevity of SARS-CoV-2 RNA to wastewater by increasing the number of facilities tested, altering frequency of sample collection, and comparing sewershed data collected to clinical patient case data.
Project Title:Optimizing SARS-CoV-2 Wastewater Based Surveillance in Urban and University Campus Settings
Awardee: Columbia University Health Sciences
Project Number:
Funding Opportunity Announcement:
Summary:This project will optimize wastewater based testing surveillance protocols of waste streams at an urban university campus encompassing dorms, research facilities and a tertiary care hospital, surrounding sewershed and wastewater treatment plant. Researchers will detect SARS-CoV-2 using qRT-PCR to estimate prevalence and viral panel-enriched metatranscriptomics to characterize viral diversity.
Project Title:Marshallese: Alternate Surveillance for COVID-19 in a Unique Population
Awardee: Washington State University
Project Number:
Funding Opportunity Announcement:
Summary:This project will generate novel data and insights into the current difficulties of stemming the pandemics in the minority communities.
Project Title:Validation of Smart Masks for Surveillance of COVID-19
Awardee: University of California, San Diego
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop a “smart mask” that changes colors when exposed to proteases of COVID-19 (Mpro and PLP proteases specific to the SARS viruses) found in saliva, the mask concentrates them from aerosolized saliva when the subject breathes and speaks. Biobank salvia samples are being leveraged to help determine the specificity of the mask.
Project Title:Multi-modal Wireless COVID Monitoring & Infection Alerts for Concentrated Populations
Awardee: Stanford University
Project Number:
Funding Opportunity Announcement:
Summary:This project will further develop a first generation detection system using heart rate data from commercially-available Fitbit Ionic wearable devices for the detection of COVID and other infectious diseases in dense concentrated populations (DCPs) using a wireless and interoperable digital health framework that centralizes all wearable-derived data and tailors its presentation and health event alert system to the IT capabilities and needs of each DCP setting.
Project Title:Early Detection, Containment, and Management of COVID-19 in Dialysis Facilities Using Multi-Modal Data Sources
Awardee: University of California, Santa Barbara
Project Number:
Funding Opportunity Announcement:
Summary:This project focuses on COVID-19 transmission and risk in dialysis facilities by combining data already being collected to predict the onset of COVID-19 in high risk dialysis patients prior to symptomatic manifestations for better management in the high-density setting. It will leverage demographic, clinical, treatment, laboratory, socioeconomic, serological, metabolomic, wearable and machine-integrated sensors, and COVID-19 surveillance data to develop mathematical and statistical models.
Project Title:Portable GC Detector for Breath-based COVID Diagnostics
Awardee: University of California, Davis
Project Number:
Funding Opportunity Announcement:
Summary:This project will detect volatile organic compunds from breath to diagnose subjects infected with SARS-CoV-2. It will use gas chromatographic separation linked to a small device that performs differential mobility spectrometry (DMS) to detect the volatile compounds.
Project Title:COVID-19 Detection through Scent Analysis with a Compact GC Device
Awardee: University of Michigan at Ann Arbor
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop field-deployable micro-gas chromatography devices for breath volatile organic compunds (VOCs) analysis. Investigators have already developed a portable 1D micro-GC device and adopted it to detect breath VOCs in acute respiratory distress syndrome in human patients.
Project Title:A Handheld Microchip for GC Analysis of Breath to Screen for COVID-19
Awardee: University of Louisville
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop a handheld breath collection tool that would be used in conjunction with a portable GC with a photoionization detector resulting in mobile breath analysis technology for rapid screening for COVID-19. The handheld tool will be a closed system for trapping select volatile organic compounds on a microfabricated silicon chip.
Project Title:Effective, Reagent-free Detection of the Odor Signature of Covid-19 Infection Using a Nano-Enabled Sensor Array
Awardee: University of Pennsylvania
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop and validate a portable automated system for detecting COVID-19 by analysis of volatile organic compounds (VOCs) from body odor. The investigators proposed to develop this e-nose system to identify VOCs in human samples by using a DNA-carbon nanotube vapor sensors array system.
Project Title:Multi-parametric Integrated Molecular Detection of SARS-CoV-2 from Biofluids by Adapting Single Extracellular Vesicle Characterization Technologies
Awardee: Ohio State University
Project Number:
Funding Opportunity Announcement:
Summary:This project will be repurposing versatile single exosome-based isolation technologies towards the detection of SARS-CoV-2 infection from biofluids. The technology employs a microfluidics system for the multi-parametric detection of both viral protein, viral RNA, and host antibodies (IgG/IgM) that are detected simultaneously by combining fluorescence-labeled antibodies and molecular beacons.
Project Title:AFS/SERS Saliva-based SARS-CoV-2 Earliest Infection and Antibodies Detection
Awardee: University of California, Los Angeles
Project Number:
Funding Opportunity Announcement:
Summary:This project will reposition the Acoustofluidic Separation (AFS) EV technology and Surface Enhanced Raman Spectroscopy (SERS) used for single vesicle isolation towards the non-invasive, early detection of SARS-CoV-2 in saliva of infected patients. The study aims to employ an integrated multi-parametric non-invasive saliva test for SARS-CoV- 2 infection, viral load and host immunity test demonstrating clinical performance that can potentially surpass current saliva-based SARS-CoV-2 tests.
Project Title:Exosome-based Non-traditional Technologies Towards Multi-Parametric and Integrated Approaches for SARS-CoV-2
Awardee: Johns Hopkins University
Project Number:
Funding Opportunity Announcement:
Summary:This project will repurpose extracellular vesicle separation and characterization technologies into a fully automated SARS-CoV-2 testing platform that is low-cost, accurate, sensitive, rapid, and practical. The device will be optimized to analyze blood, saliva, and nasopharyngeal swabs collected at home, without risking transmission to healthcare workers.
Project Title:Microfluidic Isolation and Characterization of SARS-CoV-2 and Virus Related Exosomes
Awardee: Massachusetts General Hospital
Project Number:
Funding Opportunity Announcement:
Summary:This project will optimize exosome capture technology, EVHB-Chip, a novel microfluidic technology, towards the isolation of intact SARS-CoV-2 virus, and loop mediated isothermal amplification based detection assay, and includes a full clinical validation and benchmarking of the assay. Detection assay will be compared against existing approved SARS-CoV-2 detection assays to determine detection sensitivity and specificity.
Project Title:RADx-rad Discoveries & Data: Consortium Coordination Center Program Organization
Awardee: University of California, San Diego
Project Number:
Funding Opportunity Announcement:
Summary:This project will use advanced data management to coordinate a consortium of innovative COVID-19 diagnostic technology developers. The partnership between the University of California San Diego and the University of Texas Health Science Center at Houston brings together informatics/data scientists and infectious diseases specialists who will standardize viral samples, testing and procedures, as well as data in order to integrate and share data in a meaningful manner.
Project Title:A Scalable Aptamer-based Electrochemical Biosensor for Rapid Detection of SARS-Cov-2 from Saliva
Awardee: mPOD, Inc.
Project Number:
Funding Opportunity Announcement:
Summary:This project will expand COVID-19 testing capabilities through a novel biosensor that will use oligonucleotide molecules called aptamers to bind to unique sites on the SARS-CoV-2 virus in saliva and report the data via the mPOD Inc. mobile app. The study team hypothesizes that mPOD will improve point-of-care and over-the-counter testing capacity for COVID-19 and will further enhance tracking through a rapid, affordable, aptamer-based biosensor.
Project Title:Designer DNA Nanostructure Based Biosensing for Rapid COVID-19 Detection and Monitoring using Saliva Sample
Awardee: Atom Bioworks, Inc.
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Funding Opportunity Announcement:
Summary:This project will develop a DNA Star aptamer-based detection system that can cheaply and readily detect SARS-CoV-2 in saliva samples. The novel DNA Star biosensing approach utilizes viruses unique expression of spatial patterns of antigens on their surfaces, facilitating multivalent binding to host cells for infection.
Project Title:Direct Bioelectronic Detection of SARS-Cov-2 from Saliva using Singlemolecule Field-effect Transistor Array
Awardee: Quicksilver Biosciences, Inc.
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop a new bioelectronic approach for antigen testing for COVID-19. The study will utilize DiagnostikosTM, an in-development rapid point of contact platform for direct, real- time, multiplexed, quantitative bioelectronic detection of biomolecules that employs an all-electronic detection device that functions at the single-molecule level.
Project Title:A Multimodal Platform for Oral Screening of COVID-19
Awardee: Innotech, LLC
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop a multiplexed sensor platform based on nanomaterials capable of rapid simultaneous detection of multiple components of viral particles in a field applicable electrochemical device. The device has synthetic biosensors that, in a multimodal, rapid, accurate, inexpensive, field- deployable test, will detect SARS-CoV-2.
Project Title:A SARS-CoV-2 Breathalyzer for Direct Virus Detection
Awardee: Aerosol Devices, Inc.
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop and test a novel breathalyzer for detecting aerosolized SARS-CoV-2 directly from exhaled breath in near real-time by marrying a proven, cutting-edge aerosol sampling technology with a novel and inexpensive virus detector. Aersol Devices Inc will modify its commercial bioaerosol collector, which is used to sample from the ambient environment, to enable it to collect viruses from breath samples into a concentrated liquid sample.
Project Title:SCENTinel: A Rapid Smell Test for COVID-19 Surveillance
Awardee: Monell Chemical Senses Center
Project Number:
Funding Opportunity Announcement:
Summary:This project will be testing and deploying a rapid and objective measure of smell ability, the SCENTinel test, for widespread COVID-19 surveillance.
Project Title:Rapid Olfactory Tools for Telemedicine-friendly COVID-19 Screening and Surveillance
Awardee: University of Florida
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop and implement objective, self-administered smell tests for the purpose of identifying individuals with COVID-19 prior to, or in the absence of, viral testing, as well as for use in population-level surveillance of COVID-19 spread.
Project Title:Longitudinal at Home Smell Testing to Detect Infection by SARS-CoV-2
Awardee: ADK Group, LLC
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop a native app to conduct longitudinal COVID-19 smell test, collect data on asymptomatic health care workers, symptomatic patients, and undergraduates and develop algorithms for the longitudinal smell test for personalized thresholds, differentiate smell loss from COVID-19 relative to influenza, and assess risk of developing pulmonary disease in COVID-19 infected patients.
Project Title:Diagnosing and Predicting Risk in Children with SARS-CoV-2- Related Illness
Awardee: University of California, San Diego
Project Number:
Funding Opportunity Announcement:
Summary:This project will define the antibody repertoire against all known human coronaviruses and determine how pre-existing antibody to other coronaviruses may shape the immune response in acute SARS-CoV-2 infection and multisystem inflammatory syndrome in children.
Project Title:A Data Science Approach to Identify and Manage Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 Infection and Kawasaki Disease (KD) in Pediatric Patients
Awardee: Johns Hopkins University
Project Number:
Funding Opportunity Announcement:
Summary:This project will systematically address the overlap between KD and MIS-C and create salient machine-learning based prediction models for diagnosis/identification, management, and short- and long-term outcomes of MIS-C based on our previously developed predictive models for KD in a process akin to transfer learning; also validate and evaluate the performance and clinical utility of these models in a predictive clinical decision support system for the diagnosis and management of pediatric patients presenting with features indicative of either MIS-C or KD.
Project Title:AICORE-kids: Artificial Intelligence COVID-19 Risk AssEssment for kids
Awardee: Baylor College Of Medicine
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Funding Opportunity Announcement:
Summary:This project will characterize pediatric COVID-19 and stratify incoming patients by projected (future) disease severity to improve treatment planning and direct treatment. The study proposes an artificial intelligence/machine learning approach to integrate this rich and heterogeneous dataset, characterize the spectrum of disease and identify biosignatures that predict severity in progressive disease.
Project Title:Identifying Biomarker Signatures of Prognostic Value for Multisystem Inflammatory Syndrome in Children (MIS-C)
Awardee: Connecticut Children's Medical Center
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Funding Opportunity Announcement:
Summary:This project will identify biomarkers to enable risk stratification and guide interventional studies to target COVID-19 patients at enhanced risk of developing complications and/or severe disease. The study uses biological, immunological, and molecular tests to study children and young adults (<21 years) with mild, moderate or severe SARS-CoV-2 infection through the use of biosensor chips.
Project Title:Diagnosis of MIS-C in Febrile Children
Awardee: Children's Hospital of Philadelphia
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Funding Opportunity Announcement:
Summary:This project will determine the reproducible changes in breath, urine, and salivary volatile composition in children diagnosed with multisystem inflammatory syndrome in children (MIS-C). These studies will be integrated with clinical and immunological profiling to develop (during R61 phase) and validate (during R33 phase) a novel and much-needed MIS-C diagnostic, which is expected to have a major impact on care of febrile children.
Project Title:Severity Predictors Integrating Salivary Transcriptomics and Proteomics with Multi Neural Network Intelligence in SARS-CoV2 Infection in Children (SPITS MISC)
Awardee: Central Michigan University
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Funding Opportunity Announcement:
Summary:This project will improve outcomes of children with SARS-CoV-2 by early identification and treatment of those at risk for severe illness. Central hypothesis of the study is that a model that integrates salivary biomarkers with social and clinical determinants of health will predict disease severity in children with SARS-CoV-2 infection.
Project Title:Discovery and Clinical Validation of Host Biomarkers of Disease Severity and Multi-System Inflammatory Syndrome in Children (MIS-C) with COVID-19
Awardee: University of California, San Francisco
Project Number:
Funding Opportunity Announcement:
Summary:This project will develop clinical assays that can evaluate and predict severity of pediatric COVID-19 disease, ranging from asymptomatic or mildly symptomatic to severe manifestations such as multisystem inflammatory syndrome in children (MIS-C).
Project Title:COVID-19 Network of Networks Expanding Clinical and Translational Approaches to Predict Severe Illness in Children (CONNECT to Predict Sick Children)
Awardee: Robert Wood Johnson Medical School
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Funding Opportunity Announcement:
Summary:This project will use the COVID-19 Network of Networks Expanding Clinical and Translational approaches to Predict Severe Illness in Children (CONNECT to Predict SIck Children) infrastructure, providing access to data on >15 million children. This network will systematically integrate social, epidemiological, genetic, immunological, and computational approaches to identify both population- and individual-level risk factors for severe illness.
Project Title:Virus Counter: Rapid and Sensitive Diagnostics Based on Digital Detection of Individual Pathogens
Awardee: Boston University
Project Number:
Funding Opportunity Announcement: and
Summary:This project will customize an established virus detection system that has already shown the ability to detect viruses such as Ebola and Marburg viruses to develop a focused assay for SARS-CoV-2.
Project Title:MOF-SCENT: Metal-organic Frameworks for Screening COVID-19 by Electronic-Nose Technology to Improve Selectivity and Time Response
Awardee: Missouri University of Science and Technology
Project Number:
Funding Opportunity Announcement: and
Summary:This project will develop a collection of identical electromagnetic sensors, each equipped with a distinct metal-organic frameworks (MOFs) material that can identify volatile organic compounds that indicates the COVID-19 disease.
Project Title:Broad-spectrum Detection of VOC and Non-VOC Biomarkers from Patient Exhalant using Biomimetic Multiplexed eNose Biosensor for COVID-19 Diagnosis
Awardee: University of Washington
Project Number:
Funding Opportunity Announcement: and
Summary:This project will develop a biomimetic olfaction-and gustation-based sensors for detecting volatile organic compound biomarkers against SARS-CoV-2 that also incorporate detection of biomarkers of protein and nucleic acid origin.
Project Title:A Rapid Saliva Antigen Test for SARS-CoV-2 Detection
Awardee: Brigham and Women’s Hospital
Project Number:
Funding Opportunity Announcement: and
Summary:This project will develop an ultrasensitive point of contact antigen-based diagnostics for the detection of SARS-CoV-2 by uniquely combining nanotechnology, low-cost optical sensing, and machine learning.
Project Title:A Rapid Breathalyzer Diagnostics Platform for COVID-19
Awardee: Rutgers University
Project Number:
Funding Opportunity Announcement: and
Summary:This project will develop a novel testing platform that detects SARS-CoV-2 virions in a patient’s breath. The technology captures exhaled breath into the COVID breathalyzer, where droplets and other emitted particles captured by a liquid-membrane scrubber are retrieved by a microfluidic chip designed to detect the presence of SARS-CoV-2 virus.
Project Title:RADx-rad: A Rapid, Sensitive, Point-of-care, Antigen-based Diagnostics for SARS-CoV-2
Awardee: Boston Biomedical Innovation Center (B-BIC)
Project Number:
Funding Opportunity Announcement: and
Summary:This project will develop a simple, low-cost, rapid saliva-based test using test strips that incorporate novel high affinity SARS-CoV-2 binder nanodiscs. The study aims are focused on producing and optimizing the test strip components and performing a feasibility study on archived patient samples.
Project Title:Hyperplexed sample barcoded screening for SARS-CoV-2 by Next Generation Sequencing
ɲ:National Institute of Environmental Health Sciences
Project Number:Z01-ES100475
Summary:This project will develop an easily scalable and massively paralleled multiplexed screening method by next generation sequencing with sample-specific combinatorial barcoded indexes, that detects both SARS-COV-2 viral gRNA content and the tested subject’s cellular transcriptional response to infection simultaneously and incorporates these data into a prognostic model of disease outcome.
This page last reviewed on February 7, 2022